| 1. Ronde | 16.07.2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
| 2. Ronde | 23.07.2021 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 7. Ronde | 19.08.2021 | Gimnasia de La Plata II | - | River Plate II | 3:1 | ||||
| 8. Ronde | 23.08.2021 | River Plate II | - | Aldosivi II | 3:0 | ||||
| 9. Ronde | 31.08.2021 | Sarmiento de Junín II | - | River Plate II | 3:1 | ||||
| 10. Ronde | 06.09.2021 | River Plate II | - | Independiente II | 4:0 | ||||
| 11. Ronde | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Ronde | 17.09.2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 13. Ronde | 24.09.2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 14. Ronde | 01.10.2021 | River Plate II | - | Boca Juniors II | 0:3 | ||||
| 16. Ronde | 15.10.2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Ronde | 20.10.2021 | Talleres de Córdoba II | - | River Plate II | 1:0 | ||||
| 19. Ronde | 31.10.2021 | Estudiantes II | - | River Plate II | 0:0 | ||||
| 20. Ronde | 05.11.2021 | River Plate II | - | Patronato de Paraná II | 2:0 |
Argentinië