| 1. Ronde | 08.01.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 |  |
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| 2. Ronde | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 4. Ronde | 29.01.2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
| 6. Ronde | 12.02.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | |
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| 7. Ronde | 19.02.2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 | |
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| 8. Ronde | 26.02.2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | |
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| 9. Ronde | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | |
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| 10. Ronde | 12.03.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | |
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| 11. Ronde | 19.03.2022 | CF Monterrey [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 13. Ronde | 02.04.2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 | ||||
| 14. Ronde | 06.04.2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 | ||||
| 15. Ronde | 16.04.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 | |
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| 16. Ronde | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 17. Ronde | 30.04.2022 | UANL Tigres [] | - | Atlas Guadalajara [] | 1:1 | |
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| 18. Ronde | 07.05.2022 | Atlas Guadalajara [] | - | Atlético San Luis [] | 2:2 |
Mexico