| 1. Ronde | 16.07.2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Ronde | 23.07.2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Ronde | 27.07.2021 | Newell's Old Boys II | - | Estudiantes II | 1:3 | ||||
| 11. Ronde | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 18. Ronde | 22.10.2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 19. Ronde | 29.10.2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
| 20. Ronde | 05.11.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 21. Ronde | 17.11.2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | ||||
| 22. Ronde | 24.11.2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Ronde | 30.11.2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 |
Argentinië