| 1. Ronde | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 2. Ronde | 15.01.2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 | ||||
| 4. Ronde | 29.01.2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 6. Ronde | 12.02.2022 | Club Necaxa [] | - | CF Pachuca [] | 2:1 | ||||
| 7. Ronde | 19.02.2022 | CF Pachuca [] | - | Gallos Blancos [] | 3:0 | ||||
| 8. Ronde | 26.02.2022 | CF Pachuca [] | - | FC Juárez [] | 4:0 | ||||
| 9. Ronde | 05.03.2022 | Deportivo Toluca [] | - | CF Pachuca [] | 2:4 | ||||
| 10. Ronde | 12.03.2022 | CF Pachuca [] | - | Cruz Azul [] | 4:2 | ||||
| 11. Ronde | 19.03.2022 | Puebla FC [] | - | CF Pachuca [] | 0:3 | ||||
| 13. Ronde | 03.04.2022 | FC Juárez [] | - | CF Pachuca [] | 1:4 | ||||
| 16. Ronde | 24.04.2022 | CF América [] | - | CF Pachuca [] | 4:3 |
Verenigde Staten