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| 25.09.2021 | 01:00 | Estudiantes de Río Cuarto | - | Nueva Chicago | 1:1 (0:1) | |
| 02:10 | Temperley | - | Chacarita Juniors | 0:0 (0:0) | ||
| 18:30 | Deportivo Riestra | - | San Martín de Tucumán | 0:0 (0:0) | ||
| 19:10 | Quilmes | - | Estudiantes de Caseros | 2:1 (1:0) | ||
| 21:30 | Agropecuario Argentino | - | Mitre de SdE | 1:0 (1:0) | ||
| 23:10 | Tigre | - | Alvarado | 1:0 (1:0) | ||
| 26.09.2021 | 20:10 | Gimnasia de Mendoza | - | Almirante Brown | 3:3 (2:2) | |
| 21:00 | Deportivo Maipú | - | Atlanta | 3:2 (2:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Almirante Brown | 25 | 15 | 5 | 5 | 33:23 | 10 | 50 |
| 2 |
|
Tigre | 25 | 13 | 7 | 5 | 36:17 | 19 | 46 |
| 3 |
|
Quilmes | 25 | 13 | 6 | 6 | 36:24 | 12 | 45 |
| 4 |
|
San Martín de Tucumán | 25 | 11 | 10 | 4 | 26:14 | 12 | 43 |
| 5 |
|
Gimnasia de Mendoza | 26 | 11 | 8 | 7 | 32:27 | 5 | 41 |
| 6 |
|
Belgrano de Córdoba | 25 | 11 | 6 | 8 | 25:18 | 7 | 39 |
| 7 |
|
Agropecuario Argentino | 25 | 10 | 8 | 7 | 24:20 | 4 | 38 |
| 8 |
|
Atlanta | 26 | 8 | 10 | 8 | 24:27 | -3 | 34 |
| 9 |
|
Alvarado | 26 | 9 | 6 | 11 | 23:25 | -2 | 33 |
| 10 |
|
Deportivo Riestra | 26 | 9 | 5 | 12 | 28:28 | 0 | 32 |
| 11 |
|
Deportivo Maipú | 25 | 8 | 5 | 12 | 21:29 | -8 | 29 |
|
Temperley | 25 | 7 | 8 | 10 | 21:29 | -8 | 29 | |
| 13 |
|
Estudiantes de Río Cuarto | 26 | 4 | 15 | 7 | 18:21 | -3 | 27 |
| 14 |
|
Chacarita Juniors | 25 | 6 | 9 | 10 | 26:37 | -11 | 27 |
| 15 |
|
Mitre de SdE | 26 | 6 | 8 | 12 | 25:34 | -9 | 26 |
| 16 |
|
Estudiantes de Caseros | 26 | 4 | 13 | 9 | 20:26 | -6 | 25 |
| 17 |
|
Nueva Chicago | 25 | 3 | 7 | 15 | 17:36 | -19 | 16 |
| Volgende Ronde | |
| Play-offs |
