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| 02.10.2021 | 02:05 | Belgrano de Córdoba | - | Deportivo Riestra | 1:0 (1:0) | |
| 20:00 | Chacarita Juniors | - | Deportivo Maipú | 1:2 (0:1) | ||
| 21:10 | Estudiantes de Caseros | - | Tigre | 2:1 (1:0) | ||
| 03.10.2021 | 20:30 | Mitre de SdE | - | Quilmes | 4:0 (2:0) | |
| 04.10.2021 | 20:00 | Atlanta | - | Agropecuario Argentino | 0:3 (0:3) | |
| 22:10 | San Martín de Tucumán | - | Gimnasia de Mendoza | 3:1 (0:0) | ||
| 05.10.2021 | 02:10 | Almirante Brown | - | Estudiantes de Río Cuarto | 1:1 (0:1) | |
| 20:10 | Nueva Chicago | - | Temperley | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Almirante Brown | 26 | 15 | 6 | 5 | 34:24 | 10 | 51 |
| 2 |
|
Tigre | 26 | 13 | 7 | 6 | 37:19 | 18 | 46 |
| 3 |
|
San Martín de Tucumán | 26 | 12 | 10 | 4 | 29:15 | 14 | 46 |
| 4 |
|
Quilmes | 26 | 13 | 6 | 7 | 36:28 | 8 | 45 |
| 5 |
|
Belgrano de Córdoba | 26 | 12 | 6 | 8 | 26:18 | 8 | 42 |
| 6 |
|
Agropecuario Argentino | 26 | 11 | 8 | 7 | 27:20 | 7 | 41 |
| 7 |
|
Gimnasia de Mendoza | 27 | 11 | 8 | 8 | 33:30 | 3 | 41 |
| 8 |
|
Atlanta | 27 | 8 | 10 | 9 | 24:30 | -6 | 34 |
| 9 |
|
Alvarado | 26 | 9 | 6 | 11 | 23:25 | -2 | 33 |
| 10 |
|
Deportivo Riestra | 27 | 9 | 5 | 13 | 28:29 | -1 | 32 |
| 11 |
|
Deportivo Maipú | 26 | 9 | 5 | 12 | 23:30 | -7 | 32 |
| 12 |
|
Temperley | 26 | 7 | 9 | 10 | 21:29 | -8 | 30 |
| 13 |
|
Mitre de SdE | 27 | 7 | 8 | 12 | 29:34 | -5 | 29 |
| 14 |
|
Estudiantes de Río Cuarto | 27 | 4 | 16 | 7 | 19:22 | -3 | 28 |
| 15 |
|
Estudiantes de Caseros | 27 | 5 | 13 | 9 | 22:27 | -5 | 28 |
| 16 |
|
Chacarita Juniors | 26 | 6 | 9 | 11 | 27:39 | -12 | 27 |
| 17 |
|
Nueva Chicago | 26 | 3 | 8 | 15 | 17:36 | -19 | 17 |
| Volgende Ronde | |
| Play-offs |
