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| 10.09.2022 | 20:00 | Tristan Suárez | - | Villa Dálmine | 1:1 (0:1) | |
| 20:10 | Chacarita Juniors | - | All Boys | 2:0 (0:0) | ||
| 20:30 | Agropecuario Argentino | - | Almirante Brown | 1:1 (1:1) | ||
| 20:30 | Estudiantes de Caseros | - | San Martín de San Juan | 1:0 (0:0) | ||
| 22:10 | Defensores de Belgrano | - | Deportivo Riestra | 1:0 (0:0) | ||
| 11.09.2022 | 01:40 | Instituto de Córdoba | - | Gimnasia de Jujuy | 4:0 (1:0) | |
| 16:00 | Brown de Adrogué | - | Güemes de SdE | 1:1 (0:0) | ||
| 16:00 | Guillermo Brown | - | Gimnasia de Mendoza | 0:1 (0:1) | ||
| 20:00 | Ramón Santamarina | - | Chaco For Ever | 2:2 (1:1) | ||
| 12.09.2022 | 00:30 | Atlético Rafaela | - | San Telmo | 2:1 (2:0) | |
| 00:30 | Deportivo Maipú | - | Alvarado | 0:1 (0:1) | ||
| 02:00 | Mitre de SdE | - | Temperley | 1:2 (0:2) | ||
| 20:00 | Sacachispas | - | Flandria | 1:1 (1:1) | ||
| 23:10 | Ferro Carril Oeste | - | Deportivo Morón | 1:2 (1:0) | ||
| 13.09.2022 | 00:00 | Nueva Chicago | - | Almagro | 2:3 (2:0) | |
| 01:00 | Independiente Rivadavia | - | Deportivo Madryn | 3:0 (1:0) | ||
| 01:35 | Quilmes | - | Estudiantes de Río Cuarto | 1:1 (1:1) | ||
| 02:10 | San Martín de Tucumán | - | Belgrano de Córdoba | 1:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 32 | 20 | 7 | 5 | 38:21 | 17 | 67 |
| 2 |
|
San Martín de Tucumán | 32 | 15 | 14 | 3 | 39:18 | 21 | 59 |
| 3 |
|
Instituto de Córdoba | 32 | 16 | 11 | 5 | 40:21 | 19 | 59 |
| 4 |
|
Gimnasia de Mendoza | 32 | 15 | 12 | 5 | 36:15 | 21 | 57 |
| 5 |
|
All Boys | 32 | 13 | 15 | 4 | 42:27 | 15 | 54 |
| 6 |
|
Chaco For Ever | 33 | 12 | 15 | 6 | 35:24 | 11 | 51 |
| 7 |
|
Independiente Rivadavia | 32 | 13 | 11 | 8 | 42:29 | 13 | 50 |
| 8 |
|
Defensores de Belgrano | 32 | 12 | 14 | 6 | 33:23 | 10 | 50 |
| 9 |
|
Estudiantes de Río Cuarto | 32 | 12 | 14 | 6 | 34:28 | 6 | 50 |
| 10 |
|
Estudiantes de Caseros | 32 | 14 | 8 | 10 | 29:26 | 3 | 50 |
| 11 |
|
Almagro | 32 | 14 | 8 | 10 | 32:30 | 2 | 50 |
| 12 |
|
San Martín de San Juan | 33 | 14 | 6 | 13 | 47:38 | 9 | 48 |
| 13 |
|
Deportivo Riestra | 32 | 10 | 16 | 6 | 29:24 | 5 | 46 |
| 14 |
|
Deportivo Maipú | 33 | 10 | 15 | 8 | 38:30 | 8 | 45 |
| 15 |
|
Chacarita Juniors | 32 | 11 | 10 | 11 | 46:40 | 6 | 43 |
| 16 |
|
Deportivo Morón | 32 | 9 | 16 | 7 | 27:21 | 6 | 43 |
| 17 |
|
Deportivo Madryn | 32 | 9 | 16 | 7 | 40:35 | 5 | 43 |
| 18 |
|
Quilmes | 32 | 10 | 12 | 10 | 39:40 | -1 | 42 |
| 19 |
|
Guillermo Brown | 32 | 12 | 5 | 15 | 28:39 | -11 | 41 |
| 20 |
|
Brown de Adrogué | 32 | 10 | 10 | 12 | 36:35 | 1 | 40 |
| 21 |
|
Mitre de SdE | 32 | 10 | 10 | 12 | 35:36 | -1 | 40 |
| 22 |
|
Almirante Brown | 32 | 9 | 13 | 10 | 34:36 | -2 | 40 |
| 23 |
|
Ferro Carril Oeste | 32 | 10 | 9 | 13 | 26:32 | -6 | 39 |
| 24 |
|
Atlanta | 32 | 8 | 13 | 11 | 25:29 | -4 | 37 |
| 25 |
|
Güemes de SdE | 32 | 8 | 13 | 11 | 24:28 | -4 | 37 |
| 26 |
|
Agropecuario Argentino | 32 | 7 | 15 | 10 | 25:27 | -2 | 36 |
| 27 |
|
Gimnasia de Jujuy | 32 | 9 | 9 | 14 | 32:46 | -14 | 36 |
| 28 |
|
Temperley | 32 | 7 | 14 | 11 | 30:38 | -8 | 35 |
| 29 |
|
San Telmo | 32 | 8 | 11 | 13 | 33:47 | -14 | 35 |
| 30 |
|
Atlético Rafaela | 32 | 7 | 12 | 13 | 34:38 | -4 | 33 |
| 31 |
|
Villa Dálmine | 32 | 6 | 15 | 11 | 34:47 | -13 | 33 |
| 32 |
|
Alvarado | 32 | 7 | 11 | 14 | 27:44 | -17 | 32 |
| 33 |
|
Flandria | 32 | 6 | 12 | 14 | 30:41 | -11 | 30 |
| 34 |
|
Nueva Chicago | 33 | 5 | 14 | 14 | 31:45 | -14 | 29 |
| 35 |
|
Tristan Suárez | 32 | 5 | 12 | 15 | 30:40 | -10 | 27 |
| 36 |
|
Sacachispas | 32 | 3 | 18 | 11 | 21:35 | -14 | 27 |
| 37 |
|
Ramón Santamarina | 32 | 5 | 10 | 17 | 24:52 | -28 | 25 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Degradatie |
