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| 27.03.2022 | 20:30 | Sacachispas | - | Mitre de SdE | 1:1 (0:1) | |
| 20:35 | Chacarita Juniors | - | Alvarado | 5:0 (2:0) | ||
| 21:00 | All Boys | - | Deportivo Riestra | 1:1 (1:0) | ||
| 21:00 | Guillermo Brown | - | Estudiantes de Río Cuarto | 0:1 (0:0) | ||
| 21:00 | San Telmo | - | Villa Dálmine | 0:4 (0:2) | ||
| 21:40 | Gimnasia de Mendoza | - | Belgrano de Córdoba | 0:1 (0:0) | ||
| 22:30 | San Martín de San Juan | - | Gimnasia de Jujuy | 3:0 (2:0) | ||
| 23:40 | Chaco For Ever | - | Almirante Brown | 0:0 (0:0) | ||
| 28.03.2022 | 20:00 | Brown de Adrogué | - | Almagro | 3:0 (2:0) | |
| 20:05 | Tristan Suárez | - | Quilmes | 2:2 (1:1) | ||
| 21:00 | Atlanta | - | Flandria | 3:1 (1:1) | ||
| 21:00 | Estudiantes de Caseros | - | Temperley | 0:0 (0:0) | ||
| 22:05 | Defensores de Belgrano | - | Nueva Chicago | 1:1 (1:0) | ||
| 29.03.2022 | 00:10 | Instituto de Córdoba | - | Ferro Carril Oeste | 3:2 (2:2) | |
| 01:00 | Agropecuario Argentino | - | Independiente Rivadavia | 2:1 (0:0) | ||
| 01:00 | Atlético Rafaela | - | Deportivo Madryn | 1:1 (1:1) | ||
| 01:30 | Ramón Santamarina | - | Deportivo Morón | 1:2 (1:1) | ||
| 02:10 | San Martín de Tucumán | - | Deportivo Maipú | 1:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 8 | 6 | 1 | 1 | 12:6 | 6 | 19 |
| 2 |
|
Brown de Adrogué | 8 | 5 | 3 | 0 | 15:6 | 9 | 18 |
| 3 |
|
San Martín de Tucumán | 8 | 5 | 2 | 1 | 10:5 | 5 | 17 |
| 4 |
|
Instituto de Córdoba | 8 | 4 | 4 | 0 | 10:6 | 4 | 16 |
| 5 |
|
Guillermo Brown | 8 | 5 | 1 | 2 | 9:6 | 3 | 16 |
| 6 |
|
Almirante Brown | 8 | 4 | 3 | 1 | 11:8 | 3 | 15 |
| 7 |
|
Deportivo Riestra | 8 | 3 | 5 | 0 | 6:2 | 4 | 14 |
| 8 |
|
All Boys | 7 | 3 | 4 | 0 | 9:5 | 4 | 13 |
| 9 |
|
Chaco For Ever | 8 | 2 | 6 | 0 | 8:5 | 3 | 12 |
| 10 |
|
Deportivo Madryn | 8 | 3 | 3 | 2 | 9:7 | 2 | 12 |
| 11 |
|
Defensores de Belgrano | 8 | 3 | 3 | 2 | 9:8 | 1 | 12 |
| 12 |
|
Estudiantes de Río Cuarto | 8 | 3 | 3 | 2 | 7:7 | 0 | 12 |
| 13 |
|
Chacarita Juniors | 8 | 3 | 2 | 3 | 12:11 | 1 | 11 |
| 14 |
|
San Martín de San Juan | 8 | 3 | 1 | 4 | 9:6 | 3 | 10 |
| 15 |
|
Atlanta | 8 | 2 | 4 | 2 | 9:7 | 2 | 10 |
|
Quilmes | 7 | 2 | 4 | 1 | 9:7 | 2 | 10 | |
| 17 |
|
Deportivo Morón | 8 | 2 | 4 | 2 | 5:4 | 1 | 10 |
| 18 |
|
Nueva Chicago | 8 | 2 | 4 | 2 | 8:8 | 0 | 10 |
| 19 |
|
Estudiantes de Caseros | 8 | 2 | 4 | 2 | 7:7 | 0 | 10 |
| 20 |
|
Deportivo Maipú | 8 | 2 | 4 | 2 | 6:7 | -1 | 10 |
| 21 |
|
Almagro | 8 | 3 | 1 | 4 | 6:10 | -4 | 10 |
| 22 |
|
Sacachispas | 8 | 1 | 6 | 1 | 9:8 | 1 | 9 |
| 23 |
|
Agropecuario Argentino | 8 | 2 | 3 | 3 | 7:7 | 0 | 9 |
| 24 |
|
Gimnasia de Jujuy | 8 | 2 | 3 | 3 | 8:12 | -4 | 9 |
| 25 |
|
Temperley | 8 | 2 | 2 | 4 | 8:8 | 0 | 8 |
| 26 |
|
Atlético Rafaela | 8 | 2 | 2 | 4 | 7:8 | -1 | 8 |
| 27 |
|
Independiente Rivadavia | 7 | 2 | 2 | 3 | 6:8 | -2 | 8 |
| 28 |
|
Villa Dálmine | 8 | 1 | 4 | 3 | 8:12 | -4 | 7 |
| 29 |
|
Alvarado | 8 | 1 | 4 | 3 | 9:14 | -5 | 7 |
| 30 |
|
Gimnasia de Mendoza | 7 | 1 | 3 | 3 | 5:5 | 0 | 6 |
| 31 |
|
Tristan Suárez | 8 | 0 | 6 | 2 | 11:13 | -2 | 6 |
| 32 |
|
Ferro Carril Oeste | 7 | 1 | 3 | 3 | 6:8 | -2 | 6 |
| 33 |
|
San Telmo | 7 | 1 | 3 | 3 | 4:12 | -8 | 6 |
| 34 |
|
Ramón Santamarina | 8 | 1 | 2 | 5 | 8:12 | -4 | 5 |
| 35 |
|
Flandria | 8 | 1 | 2 | 5 | 7:14 | -7 | 5 |
| 36 |
|
Güemes de SdE | 7 | 0 | 4 | 3 | 4:9 | -5 | 4 |
| 37 |
|
Mitre de SdE | 7 | 0 | 3 | 4 | 4:9 | -5 | 3 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Degradatie |
