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| 30.04.2021 | 15:00 | Vélez Sarsfield II | - | Patronato de Paraná II | 2:1 (0:0) | |
| 15:00 | Rosario Central II | - | Newell's Old Boys II | 0:2 (0:0) | ||
| 15:00 | Defensa y Justicia II | - | Unión de Santa Fe II | 2:1 (0:1) | ||
| 15:00 | Independiente II | - | Atlético Tucumán II | 1:0 (1:0) | ||
| 15:00 | Talleres de Córdoba II | - | Huracán II | 0:1 (0:0) | ||
| 15:00 | Boca Juniors II | - | Lanús II | 3:2 (1:1) | ||
| 15:00 | San Lorenzo II | - | Godoy Cruz II | 0:1 (0:0) | ||
| 15:00 | Sarmiento de Junín II | - | Gimnasia de La Plata II | 1:2 (0:2) | ||
| 15:00 | Central Córdoba SdE II | - | Racing Club II | 1:3 (0:3) | ||
| 15:00 | Aldosivi II | - | Argentinos Juniors II | 1:1 (0:1) | ||
| 15:00 | Estudiantes II | - | Platense II | 3:0 (2:0) | ||
| 15:00 | Colón de Santa Fe II | - | Arsenal de Sarandí II | 2:0 (2:0) | ||
| 16:00 | Banfield II | - | River Plate II | 1:2 (0:1) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate II | 12 | 10 | 2 | 0 | 24:7 | 17 | 32 |
| 2 |
|
Argentinos Juniors II | 12 | 6 | 5 | 1 | 15:5 | 10 | 23 |
| 3 |
|
Estudiantes II | 12 | 7 | 2 | 3 | 19:11 | 8 | 23 |
| 4 |
|
Godoy Cruz II | 12 | 6 | 4 | 2 | 13:7 | 6 | 22 |
| 5 |
|
Racing Club II | 12 | 5 | 2 | 5 | 13:13 | 0 | 17 |
| 6 |
|
Aldosivi II | 12 | 5 | 1 | 6 | 19:16 | 3 | 16 |
| 7 |
|
Rosario Central II | 12 | 3 | 5 | 4 | 15:13 | 2 | 14 |
| 8 |
|
Banfield II | 12 | 3 | 5 | 4 | 13:16 | -3 | 14 |
| 9 |
|
Platense II | 12 | 3 | 4 | 5 | 18:19 | -1 | 13 |
| 10 |
|
Colón de Santa Fe II | 12 | 3 | 4 | 5 | 9:17 | -8 | 13 |
| 11 |
|
San Lorenzo II | 12 | 2 | 4 | 6 | 13:18 | -5 | 10 |
| 12 |
|
Central Córdoba SdE II | 12 | 2 | 1 | 9 | 8:26 | -18 | 7 |
| 13 |
|
Arsenal de Sarandí II | 12 | 0 | 6 | 6 | 10:22 | -12 | 6 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 12 | 8 | 3 | 1 | 26:13 | 13 | 27 |
| 2 |
|
Sarmiento de Junín II | 12 | 7 | 2 | 3 | 26:19 | 7 | 23 |
| 3 |
|
Independiente II | 12 | 6 | 3 | 3 | 23:17 | 6 | 21 |
| 4 |
|
Newell's Old Boys II | 12 | 6 | 2 | 4 | 21:17 | 4 | 20 |
| 5 |
|
Defensa y Justicia II | 12 | 5 | 4 | 3 | 20:17 | 3 | 19 |
| 6 |
|
Vélez Sarsfield II | 12 | 5 | 3 | 4 | 18:15 | 3 | 18 |
| 7 |
|
Huracán II | 12 | 4 | 5 | 3 | 17:20 | -3 | 17 |
| 8 |
|
Gimnasia de La Plata II | 12 | 4 | 4 | 4 | 14:14 | 0 | 16 |
| 9 |
|
Unión de Santa Fe II | 12 | 4 | 3 | 5 | 18:19 | -1 | 15 |
| 10 |
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Atlético Tucumán II | 12 | 3 | 3 | 6 | 17:20 | -3 | 12 |
| 11 |
|
Patronato de Paraná II | 12 | 2 | 4 | 6 | 9:17 | -8 | 10 |
| 12 |
|
Lanús II | 12 | 2 | 2 | 8 | 21:30 | -9 | 8 |
| 13 |
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Talleres de Córdoba II | 12 | 1 | 5 | 6 | 13:24 | -11 | 8 |
| Play-offs | |
| Play-offs |
