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| 12.10.2022 | 15:00 | Unión de Santa Fe II | - | Defensa y Justicia II | 0:1 (0:0) | |
| 15:00 | Platense II | - | River Plate II | 0:1 (0:1) | ||
| 16:00 | Rosario Central II | - | Atlético Tucumán II | 2:1 (0:1) | ||
| 16:00 | Racing Club II | - | Colón de Santa Fe II | 2:2 (0:1) | ||
| 13.10.2022 | 15:00 | Patronato de Paraná II | - | Lanús II | 1:1 (0:0) | |
| 15:00 | Estudiantes II | - | Huracán II | 1:2 (1:1) | ||
| 15:00 | Barracas Central II | - | Independiente II | 0:1 (0:0) | ||
| 16:00 | Argentinos Juniors II | - | Godoy Cruz II | 2:1 (1:1) | ||
| 16:00 | Central Córdoba SdE II | - | Arsenal de Sarandí II | 1:1 (0:0) | ||
| 17:00 | Tigre II | - | Newell's Old Boys II | 2:1 (0:0) | ||
| 14.10.2022 | 15:00 | Boca Juniors II | - | Sarmiento de Junín II | 2:0 (2:0) | |
| 16:00 | Talleres de Córdoba II | - | Vélez Sarsfield II | 0:2 (0:1) | ||
| 16:00 | San Lorenzo II | - | Gimnasia de La Plata II | 3:1 (1:0) | ||
| 16:00 | Banfield II | - | Aldosivi II | 1:4 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 25 | 16 | 3 | 6 | 43:19 | 24 | 51 |
| 2 |
|
Vélez Sarsfield II | 25 | 16 | 2 | 7 | 44:17 | 27 | 50 |
| 3 |
|
Tigre II | 25 | 12 | 8 | 5 | 32:25 | 7 | 44 |
| 4 |
|
River Plate II | 25 | 14 | 1 | 10 | 27:24 | 3 | 43 |
| 5 |
|
Huracán II | 25 | 13 | 3 | 9 | 49:38 | 11 | 42 |
| 6 |
|
Independiente II | 25 | 12 | 6 | 7 | 39:28 | 11 | 42 |
| 7 |
|
Argentinos Juniors II | 25 | 11 | 9 | 5 | 35:24 | 11 | 42 |
| 8 |
|
Newell's Old Boys II | 25 | 11 | 8 | 6 | 33:25 | 8 | 41 |
| 9 |
|
Lanús II | 25 | 12 | 5 | 8 | 40:38 | 2 | 41 |
| 10 |
|
Gimnasia de La Plata II | 25 | 11 | 6 | 8 | 44:32 | 12 | 39 |
| 11 |
|
Defensa y Justicia II | 25 | 11 | 5 | 9 | 27:30 | -3 | 38 |
| 12 |
|
Rosario Central II | 25 | 10 | 7 | 8 | 43:33 | 10 | 37 |
| 13 |
|
Talleres de Córdoba II | 25 | 11 | 4 | 10 | 39:34 | 5 | 37 |
| 14 |
|
Colón de Santa Fe II | 25 | 8 | 9 | 8 | 34:35 | -1 | 33 |
| 15 |
|
Unión de Santa Fe II | 25 | 8 | 9 | 8 | 21:22 | -1 | 33 |
| 16 |
|
San Lorenzo II | 25 | 10 | 3 | 12 | 30:32 | -2 | 33 |
| 17 |
|
Platense II | 25 | 7 | 11 | 7 | 24:23 | 1 | 32 |
| 18 |
|
Godoy Cruz II | 25 | 8 | 7 | 10 | 33:34 | -1 | 31 |
| 19 |
|
Estudiantes II | 25 | 7 | 9 | 9 | 22:26 | -4 | 30 |
| 20 |
|
Banfield II | 25 | 8 | 6 | 11 | 24:31 | -7 | 30 |
| 21 |
|
Arsenal de Sarandí II | 25 | 6 | 11 | 8 | 24:25 | -1 | 29 |
| 22 |
|
Sarmiento de Junín II | 25 | 8 | 4 | 13 | 20:37 | -17 | 28 |
| 23 |
|
Racing Club II | 25 | 6 | 9 | 10 | 32:31 | 1 | 27 |
| 24 |
|
Central Córdoba SdE II | 25 | 7 | 6 | 12 | 22:36 | -14 | 27 |
| 25 |
|
Atlético Tucumán II | 25 | 6 | 5 | 14 | 29:41 | -12 | 23 |
| 26 |
|
Aldosivi II | 25 | 6 | 4 | 15 | 32:51 | -19 | 22 |
| 27 |
|
Patronato de Paraná II | 25 | 5 | 6 | 14 | 19:40 | -21 | 21 |
| 28 |
|
Barracas Central II | 25 | 6 | 2 | 17 | 17:47 | -30 | 20 |
