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| 15.05.2022 | 20:15 | Douglas Haig | - | Juventud Unida de Gualeguaychú | 3:2 (2:0) | |
| 20:30 | Defensores de Pronunciamiento | - | Sportivo Las Parejas | 2:1 (0:1) | ||
| 20:30 | Sarmiento de Resistencia | - | Gimnasia y Esgrima (CdU) | 0:0 (0:0) | ||
| 20:30 | Unión de Sunchales | - | Atlético Paraná | 1:0 (0:0) | ||
| 21:00 | Defensores Belgrano (VR) | - | Boca Unidos | 0:1 (0:0) | ||
| 21:00 | San Martín de Formosa | - | Crucero del Norte | 1:1 (0:0) | ||
| 21:30 | Belgrano de San Francisco | - | Racing de Córdoba | 0:0 (0:0) | ||
| 22:00 | Central Norte | - | Juventud Antoniana | 1:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 8 | 6 | 2 | 0 | 16:1 | 15 | 20 |
| 2 |
|
Central Norte | 8 | 5 | 3 | 0 | 8:1 | 7 | 18 |
| 3 |
|
Crucero del Norte | 9 | 5 | 2 | 2 | 11:10 | 1 | 17 |
| 4 |
|
Sarmiento de Resistencia | 9 | 4 | 4 | 1 | 8:2 | 6 | 16 |
| 5 |
|
Douglas Haig | 9 | 5 | 0 | 4 | 14:9 | 5 | 15 |
| 6 |
|
San Martín de Formosa | 8 | 4 | 3 | 1 | 10:5 | 5 | 15 |
| 7 |
|
Gimnasia y Tiro de Salta | 8 | 4 | 1 | 3 | 6:8 | -2 | 13 |
| 8 |
|
Gimnasia y Esgrima (CdU) | 8 | 3 | 3 | 2 | 8:5 | 3 | 12 |
| 9 |
|
Boca Unidos | 8 | 3 | 3 | 2 | 6:6 | 0 | 12 |
| 10 |
|
Sportivo Las Parejas | 9 | 3 | 2 | 4 | 10:12 | -2 | 11 |
| 11 |
|
Belgrano de San Francisco | 9 | 3 | 2 | 4 | 8:10 | -2 | 11 |
| 12 |
|
Juventud Antoniana | 9 | 2 | 3 | 4 | 3:10 | -7 | 9 |
| 13 |
|
Unión de Sunchales | 8 | 2 | 2 | 4 | 5:8 | -3 | 8 |
| 14 |
|
Defensores de Pronunciamiento | 8 | 2 | 1 | 5 | 6:11 | -5 | 7 |
| 15 |
|
Defensores Belgrano (VR) | 9 | 1 | 3 | 5 | 7:10 | -3 | 6 |
| 16 |
|
Atlético Paraná | 9 | 1 | 2 | 6 | 5:13 | -8 | 5 |
| 17 |
|
Juventud Unida de Gualeguaychú | 8 | 1 | 0 | 7 | 4:14 | -10 | 3 |
| Play-offs |
