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| 19.10.2021 | 19:00 | FC Cartagena | - | Sporting Gijón | 1:0 (0:0) | |
| 19:00 | SD Huesca | - | Málaga CF | 0:0 (0:0) | ||
| 21:00 | CD Tenerife | - | SD Eibar | 0:1 (0:0) | ||
| 20.10.2021 | 19:00 | CF Fuenlabrada | - | SD Amorebieta | 0:0 (0:0) | |
| 19:00 | Real Valladolid | - | UD Ibiza | 1:1 (0:0) | ||
| 21:00 | AD Alcorcón | - | CD Leganés | 3:3 (2:2) | ||
| 21:00 | CD Lugo | - | UD Las Palmas | 2:0 (2:0) | ||
| 21.10.2021 | 18:45 | UD Almería | - | Real Sociedad B | 3:1 (1:1) | |
| 19:00 | Real Zaragoza | - | SD Ponferradina | 1:1 (0:0) | ||
| 21:00 | CD Mirandés | - | Girona FC | 1:2 (0:2) | ||
| 21:00 | Real Oviedo | - | Burgos CF | 1:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 11 | 7 | 1 | 3 | 21:10 | 11 | 22 |
| 2 |
|
Sporting Gijón | 11 | 6 | 3 | 2 | 14:10 | 4 | 21 |
| 3 |
|
SD Eibar | 11 | 6 | 3 | 2 | 17:13 | 4 | 21 |
| 4 |
|
SD Ponferradina | 11 | 5 | 4 | 2 | 14:9 | 5 | 19 |
| 5 |
|
FC Cartagena | 11 | 6 | 0 | 5 | 16:17 | -1 | 18 |
| 6 |
|
UD Las Palmas | 11 | 4 | 5 | 2 | 15:13 | 2 | 17 |
| 7 |
|
CD Tenerife | 11 | 5 | 2 | 4 | 13:11 | 2 | 17 |
| 8 |
|
Real Valladolid | 11 | 4 | 4 | 3 | 13:11 | 2 | 16 |
| 9 |
|
CF Fuenlabrada | 11 | 3 | 6 | 2 | 9:7 | 2 | 15 |
| 10 |
|
CD Lugo | 11 | 3 | 6 | 2 | 13:12 | 1 | 15 |
| 11 |
|
SD Huesca | 11 | 4 | 3 | 4 | 14:10 | 4 | 15 |
| 12 |
|
CD Mirandés | 11 | 4 | 2 | 5 | 17:16 | 1 | 14 |
| 13 |
|
Málaga CF | 11 | 3 | 5 | 3 | 9:12 | -3 | 14 |
| 14 |
|
Real Oviedo | 11 | 2 | 7 | 2 | 11:11 | 0 | 13 |
| 15 |
|
Burgos CF | 11 | 3 | 4 | 4 | 10:9 | 1 | 13 |
| 16 |
|
UD Ibiza | 11 | 2 | 6 | 3 | 12:17 | -5 | 12 |
| 17 |
|
Real Sociedad B | 11 | 2 | 5 | 4 | 11:13 | -2 | 11 |
| 18 |
|
Real Zaragoza | 11 | 1 | 8 | 2 | 7:9 | -2 | 11 |
| 19 |
|
Girona FC | 11 | 3 | 2 | 6 | 9:13 | -4 | 11 |
| 20 |
|
CD Leganés | 11 | 2 | 4 | 5 | 11:15 | -4 | 10 |
| 21 |
|
SD Amorebieta | 11 | 1 | 5 | 5 | 10:16 | -6 | 8 |
| 22 |
|
AD Alcorcón | 11 | 2 | 1 | 8 | 9:21 | -12 | 7 |
| Promotie | |
| Play-offs | |
| Degradatie |
