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| 15.10.2021 | 21:00 | SD Eibar | - | UD Almería | 1:0 (1:0) | |
| 16.10.2021 | 16:00 | SD Amorebieta | - | FC Cartagena | 2:3 (1:1) | |
| 16:00 | Girona FC | - | SD Huesca | 1:3 (0:0) | ||
| 18:15 | UD Las Palmas | - | CD Tenerife | 2:1 (1:0) | ||
| 20:30 | Málaga CF | - | Real Zaragoza | 1:1 (1:1) | ||
| 21:00 | Sporting Gijón | - | AD Alcorcón | 1:0 (0:0) | ||
| 17.10.2021 | 14:00 | UD Ibiza | - | CD Mirandés | 0:2 (0:1) | |
| 16:00 | CD Leganés | - | Real Valladolid | 0:2 (0:1) | ||
| 18:15 | Burgos CF | - | CD Lugo | 1:1 (1:1) | ||
| 18:15 | Real Sociedad B | - | Real Oviedo | 1:1 (0:0) | ||
| 21:00 | SD Ponferradina | - | CF Fuenlabrada | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sporting Gijón | 10 | 6 | 3 | 1 | 14:9 | 5 | 21 |
| 2 |
|
UD Almería | 10 | 6 | 1 | 3 | 18:9 | 9 | 19 |
| 3 |
|
SD Ponferradina | 10 | 5 | 3 | 2 | 13:8 | 5 | 18 |
| 4 |
|
SD Eibar | 10 | 5 | 3 | 2 | 16:13 | 3 | 18 |
| 5 |
|
UD Las Palmas | 10 | 4 | 5 | 1 | 15:11 | 4 | 17 |
| 6 |
|
CD Tenerife | 10 | 5 | 2 | 3 | 13:10 | 3 | 17 |
| 7 |
|
FC Cartagena | 10 | 5 | 0 | 5 | 15:17 | -2 | 15 |
| 8 |
|
Real Valladolid | 10 | 4 | 3 | 3 | 12:10 | 2 | 15 |
| 9 |
|
CD Mirandés | 10 | 4 | 2 | 4 | 16:14 | 2 | 14 |
| 10 |
|
CF Fuenlabrada | 10 | 3 | 5 | 2 | 9:7 | 2 | 14 |
| 11 |
|
SD Huesca | 10 | 4 | 2 | 4 | 14:10 | 4 | 14 |
| 12 |
|
Málaga CF | 10 | 3 | 4 | 3 | 9:12 | -3 | 13 |
| 13 |
|
Real Oviedo | 10 | 2 | 7 | 1 | 10:8 | 2 | 13 |
| 14 |
|
CD Lugo | 10 | 2 | 6 | 2 | 11:12 | -1 | 12 |
| 15 |
|
Real Sociedad B | 10 | 2 | 5 | 3 | 10:10 | 0 | 11 |
| 16 |
|
UD Ibiza | 10 | 2 | 5 | 3 | 11:16 | -5 | 11 |
| 17 |
|
Real Zaragoza | 10 | 1 | 7 | 2 | 6:8 | -2 | 10 |
| 18 |
|
Burgos CF | 10 | 2 | 4 | 4 | 7:8 | -1 | 10 |
| 19 |
|
CD Leganés | 10 | 2 | 3 | 5 | 8:12 | -4 | 9 |
| 20 |
|
Girona FC | 10 | 2 | 2 | 6 | 7:12 | -5 | 8 |
| 21 |
|
SD Amorebieta | 10 | 1 | 4 | 5 | 10:16 | -6 | 7 |
| 22 |
|
AD Alcorcón | 10 | 2 | 0 | 8 | 6:18 | -12 | 6 |
| Promotie | |
| Play-offs | |
| Degradatie |
