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| 22.10.2021 | 21:00 | SD Eibar | - | FC Cartagena | 2:1 (2:0) | |
| 23.10.2021 | 16:00 | UD Ibiza | - | CF Fuenlabrada | 3:1 (1:1) | |
| 18:15 | Sporting Gijón | - | Real Valladolid | 1:2 (0:1) | ||
| 20:30 | Málaga CF | - | CD Lugo | 1:0 (1:0) | ||
| 21:00 | CD Leganés | - | CD Tenerife | 1:2 (0:1) | ||
| 24.10.2021 | 14:00 | SD Amorebieta | - | Real Sociedad B | 1:2 (0:1) | |
| 14:00 | CD Mirandés | - | UD Almería | 1:4 (0:3) | ||
| 18:15 | Burgos CF | - | SD Huesca | 3:1 (1:1) | ||
| 18:15 | SD Ponferradina | - | Real Oviedo | 1:2 (0:1) | ||
| 21:00 | UD Las Palmas | - | AD Alcorcón | 3:0 (1:0) | ||
| 25.10.2021 | 21:00 | Girona FC | - | Real Zaragoza | 1:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 12 | 8 | 1 | 3 | 25:11 | 14 | 25 |
| 2 |
|
SD Eibar | 12 | 7 | 3 | 2 | 19:14 | 5 | 24 |
| 3 |
|
Sporting Gijón | 12 | 6 | 3 | 3 | 15:12 | 3 | 21 |
| 4 |
|
UD Las Palmas | 12 | 5 | 5 | 2 | 18:13 | 5 | 20 |
| 5 |
|
CD Tenerife | 12 | 6 | 2 | 4 | 15:12 | 3 | 20 |
| 6 |
|
SD Ponferradina | 12 | 5 | 4 | 3 | 15:11 | 4 | 19 |
| 7 |
|
Real Valladolid | 12 | 5 | 4 | 3 | 15:12 | 3 | 19 |
| 8 |
|
FC Cartagena | 12 | 6 | 0 | 6 | 17:19 | -2 | 18 |
| 9 |
|
Málaga CF | 12 | 4 | 5 | 3 | 10:12 | -2 | 17 |
| 10 |
|
Real Oviedo | 12 | 3 | 7 | 2 | 13:12 | 1 | 16 |
| 11 |
|
Burgos CF | 12 | 4 | 4 | 4 | 13:10 | 3 | 16 |
| 12 |
|
CD Lugo | 12 | 3 | 6 | 3 | 13:13 | 0 | 15 |
| 13 |
|
CF Fuenlabrada | 12 | 3 | 6 | 3 | 10:10 | 0 | 15 |
| 14 |
|
UD Ibiza | 12 | 3 | 6 | 3 | 15:18 | -3 | 15 |
| 15 |
|
SD Huesca | 12 | 4 | 3 | 5 | 15:13 | 2 | 15 |
| 16 |
|
Real Sociedad B | 12 | 3 | 5 | 4 | 13:14 | -1 | 14 |
| 17 |
|
CD Mirandés | 12 | 4 | 2 | 6 | 18:20 | -2 | 14 |
| 18 |
|
Real Zaragoza | 12 | 1 | 9 | 2 | 8:10 | -2 | 12 |
| 19 |
|
Girona FC | 12 | 3 | 3 | 6 | 10:14 | -4 | 12 |
| 20 |
|
CD Leganés | 12 | 2 | 4 | 6 | 12:17 | -5 | 10 |
| 21 |
|
SD Amorebieta | 12 | 1 | 5 | 6 | 11:18 | -7 | 8 |
| 22 |
|
AD Alcorcón | 12 | 2 | 1 | 9 | 9:24 | -15 | 7 |
| Promotie | |
| Play-offs | |
| Degradatie |
