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| 12.11.2021 | 21:00 | Sporting Gijón | - | Real Sociedad B | 0:1 (0:0) | |
| 13.11.2021 | 16:00 | Real Valladolid | - | CF Fuenlabrada | 3:0 (1:0) | |
| 18:15 | CD Mirandés | - | SD Huesca | 0:1 (0:0) | ||
| 18:15 | SD Eibar | - | AD Alcorcón | 2:1 (2:1) | ||
| 20:30 | UD Las Palmas | - | Real Zaragoza | 2:3 (1:1) | ||
| 14.11.2021 | 14:00 | SD Amorebieta | - | CD Lugo | 1:3 (1:2) | |
| 16:00 | Girona FC | - | FC Cartagena | 2:0 (1:0) | ||
| 16:00 | UD Ibiza | - | UD Almería | 0:1 (0:1) | ||
| 18:15 | Burgos CF | - | SD Ponferradina | 1:0 (1:0) | ||
| 18:15 | CD Leganés | - | Real Oviedo | 0:0 (0:0) | ||
| 15.11.2021 | 21:00 | Málaga CF | - | CD Tenerife | 1:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 16 | 12 | 1 | 3 | 30:11 | 19 | 37 |
| 2 |
|
SD Eibar | 16 | 9 | 4 | 3 | 22:17 | 5 | 31 |
| 3 |
|
Real Valladolid | 16 | 8 | 4 | 4 | 24:17 | 7 | 28 |
| 4 |
|
CD Tenerife | 16 | 8 | 3 | 5 | 21:14 | 7 | 27 |
| 5 |
|
UD Las Palmas | 16 | 7 | 6 | 3 | 24:18 | 6 | 27 |
| 6 |
|
SD Ponferradina | 16 | 7 | 5 | 4 | 19:14 | 5 | 26 |
| 7 |
|
Málaga CF | 16 | 6 | 5 | 5 | 15:18 | -3 | 23 |
| 8 |
|
Real Zaragoza | 16 | 4 | 10 | 2 | 15:13 | 2 | 22 |
| 9 |
|
UD Ibiza | 16 | 5 | 7 | 4 | 18:19 | -1 | 22 |
| 10 |
|
Sporting Gijón | 16 | 6 | 4 | 6 | 16:17 | -1 | 22 |
| 11 |
|
FC Cartagena | 16 | 7 | 1 | 8 | 21:24 | -3 | 22 |
| 12 |
|
Girona FC | 16 | 6 | 3 | 7 | 18:18 | 0 | 21 |
| 13 |
|
Real Oviedo | 16 | 4 | 9 | 3 | 16:15 | 1 | 21 |
| 14 |
|
SD Huesca | 16 | 5 | 5 | 6 | 18:17 | 1 | 20 |
| 15 |
|
CD Lugo | 16 | 4 | 7 | 5 | 20:20 | 0 | 19 |
| 16 |
|
Burgos CF | 16 | 5 | 4 | 7 | 14:17 | -3 | 19 |
| 17 |
|
CD Mirandés | 16 | 5 | 3 | 8 | 23:27 | -4 | 18 |
| 18 |
|
Real Sociedad B | 16 | 4 | 5 | 7 | 15:18 | -3 | 17 |
| 19 |
|
CF Fuenlabrada | 16 | 3 | 7 | 6 | 12:17 | -5 | 16 |
| 20 |
|
CD Leganés | 16 | 3 | 6 | 7 | 15:19 | -4 | 15 |
| 21 |
|
SD Amorebieta | 16 | 2 | 7 | 7 | 19:25 | -6 | 13 |
| 22 |
|
AD Alcorcón | 16 | 2 | 2 | 12 | 13:33 | -20 | 8 |
| Promotie | |
| Play-offs | |
| Degradatie |
