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| U | UANL Tigres | - | CF Monterrey | 1:3 (1:2) | ||
| R | CF Monterrey | - | UANL Tigres | 1:2 (0:2) | ||
| U: 12.05.2016 02:00 | R: 15.05.2016 02:00 | Winnaars: CF Monterrey | ||||
| U | Monarcas Morelia | - | Club León | 1:1 (0:0) | ||
| R | Club León | - | Monarcas Morelia | 4:1 (1:0) | ||
| U: 12.05.2016 04:00 | R: 15.05.2016 04:06 | Winnaars: Club León | ||||
| U | Santos Laguna | - | CF Pachuca | 1:1 (0:1) | ||
| R | CF Pachuca | - | Santos Laguna | 3:2 (1:1) | ||
| U: 13.05.2016 02:00 | R: 16.05.2016 03:06 | Winnaars: CF Pachuca | ||||
| U | Deportivo Guadalajara | - | CF América | 0:0 (0:0) | ||
| R | CF América | - | Deportivo Guadalajara | 2:1 (1:1) | ||
| U: 13.05.2016 04:00 | R: 16.05.2016 01:00 | Winnaars: CF América | ||||
