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| U | Deportivo Guadalajara | - | Club León | 1:1 (0:1) | ||
| R | Club León | - | Deportivo Guadalajara | 1:0 (1:0) | ||
| U: 03.12.2020 04:05 | R: 06.12.2020 04:00 | Winnaars: Club León | ||||
| U | Cruz Azul | - | Pumas UNAM | 4:0 (3:0) | ||
| R | Pumas UNAM | - | Cruz Azul | 4:0 (3:0) | ||
| U: 04.12.2020 04:00 | R: 07.12.2020 01:30 | |||||
