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| 11.03.2022 | 17:00 | AS Trenčín | - | FK Pohronie | 2:0 (0:0) | |
| 12.03.2022 | 15:00 | FK Senica | - | MFK Zemplín Michalovce | 2:1 (1:0) | |
| 15:00 | Zlaté Moravce | - | Tatran Liptovský Mikuláš | 0:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Senica | 24 | 8 | 6 | 10 | 24:35 | -11 | 30 |
| 2 |
|
AS Trenčín | 24 | 7 | 7 | 10 | 34:34 | 0 | 28 |
| 3 |
|
Tatran Liptovský Mikuláš | 24 | 7 | 6 | 11 | 30:44 | -14 | 27 |
| 4 |
|
MFK Zemplín Michalovce | 24 | 8 | 2 | 14 | 22:33 | -11 | 26 |
| 5 |
|
Zlaté Moravce | 24 | 5 | 7 | 12 | 23:37 | -14 | 22 |
| 6 |
|
FK Pohronie | 24 | 2 | 4 | 18 | 19:50 | -31 | 10 |
| Play-offs | |
| Degradatie |
