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| 19.03.2022 | 15:00 | AS Trenčín | - | FK Senica | 4:1 (2:1) | |
| 15:00 | MFK Zemplín Michalovce | - | Zlaté Moravce | 1:0 (0:0) | ||
| 15:00 | FK Pohronie | - | Tatran Liptovský Mikuláš | 1:1 (1:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Trenčín | 25 | 8 | 7 | 10 | 38:35 | 3 | 31 |
| 2 |
|
FK Senica | 25 | 8 | 6 | 11 | 25:39 | -14 | 30 |
| 3 |
|
MFK Zemplín Michalovce | 25 | 9 | 2 | 14 | 23:33 | -10 | 29 |
| 4 |
|
Tatran Liptovský Mikuláš | 25 | 7 | 7 | 11 | 31:45 | -14 | 28 |
| 5 |
|
Zlaté Moravce | 25 | 5 | 7 | 13 | 23:38 | -15 | 22 |
| 6 |
|
FK Pohronie | 25 | 2 | 5 | 18 | 20:51 | -31 | 11 |
| Play-offs | |
| Degradatie |
