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| 02.04.2022 | 16:00 | Tatran Liptovský Mikuláš | - | AS Trenčín | 0:3 (0:2) | |
| 18:00 | Zlaté Moravce | - | FK Senica | 3:2 (1:1) | ||
| 18:00 | MFK Zemplín Michalovce | - | FK Pohronie | 1:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Trenčín | 26 | 9 | 7 | 10 | 41:35 | 6 | 34 |
| 2 |
|
MFK Zemplín Michalovce | 26 | 10 | 2 | 14 | 24:33 | -9 | 32 |
| 3 |
|
FK Senica | 26 | 8 | 6 | 12 | 27:42 | -15 | 30 |
| 4 |
|
Tatran Liptovský Mikuláš | 26 | 7 | 7 | 12 | 31:48 | -17 | 28 |
| 5 |
|
Zlaté Moravce | 26 | 6 | 7 | 13 | 26:40 | -14 | 25 |
| 6 |
|
FK Pohronie | 26 | 2 | 5 | 19 | 20:52 | -32 | 11 |
| Play-offs | |
| Degradatie |
