| 1. Ronde | 22.08.2021 | FC Crotone | - | Como 1907 | 2:2 | ||||
| 2. Ronde | 29.08.2021 | AS Cittadella | - | FC Crotone | 4:2 | ||||
| 3. Ronde | 11.09.2021 | FC Crotone | - | Reggina 1914 | 1:1 |  |
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| 4. Ronde | 17.09.2021 | Brescia Calcio | - | FC Crotone | 2:2 |  |
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| 5. Ronde | 21.09.2021 | FC Crotone | - | US Lecce | 0:3 | ||||
| 6. Ronde | 25.09.2021 | Cosenza Calcio | - | FC Crotone | 1:0 | |
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| 7. Ronde | 02.10.2021 | FC Crotone | - | Ascoli Calcio | 2:2 | ||||
| 13. Ronde | 20.11.2021 | AC Perugia Calcio | - | FC Crotone | 2:0 | ||||
| 14. Ronde | 26.11.2021 | FC Crotone | - | L.R. Vicenza | 0:1 | |
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| 16. Ronde | 04.12.2021 | FC Crotone | - | SPAL 2013 Ferrara | 1:2 | ||||
| 17. Ronde | 10.12.2021 | US Cremonese | - | FC Crotone | 3:2 | |
Engeland