| 1. Ronde | 17.07.2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 | ||||
| 2. Ronde | 27.07.2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 3. Ronde | 30.07.2021 | Newell's Old Boys | - | Estudiantes | 4:2 | ||||
| 4. Ronde | 02.08.2021 | Patronato de Paraná | - | Newell's Old Boys | 0:0 | ||||
| 5. Ronde | 07.08.2021 | Newell's Old Boys | - | Platense | 1:0 | ||||
| 6. Ronde | 16.08.2021 | Racing Club | - | Newell's Old Boys | 2:0 | ||||
| 7. Ronde | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Ronde | 25.08.2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
| 9. Ronde | 30.08.2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Ronde | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 11. Ronde | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Ronde | 20.09.2021 | Lanús | - | Newell's Old Boys | 1:2 |  |
|||
| 13. Ronde | 28.09.2021 | Newell's Old Boys | - | Huracán | 0:1 | ||||
| 14. Ronde | 02.10.2021 | Godoy Cruz | - | Newell's Old Boys | 2:2 | ||||
| 15. Ronde | 09.10.2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 | |
|||
| 24. Ronde | 07.12.2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Ronde | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
Argentinië