| 3. Ronde | 21.08.2021 | Gil Vicente [A-jun] | - | Vitória Guimarães [A-jun] | 0:2 | ||||
| 7. Ronde | 25.09.2021 | Vitória Guimarães [A-jun] | - | FC Porto [A-jun] | 0:2 | ||||
| 8. Ronde | 02.10.2021 | Sporting Braga [A-jun] | - | Vitória Guimarães [A-jun] | 2:1 | ||||
| 15. Ronde | 01.12.2021 | Leixões SC [A-jun] | - | Vitória Guimarães [A-jun] | 0:4 | ||||
| 16. Ronde | 04.12.2021 | FC Vizela [A-jun] | - | Vitória Guimarães [A-jun] | 2:3 |  |
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| 17. Ronde | 11.12.2021 | Vitória Guimarães [A-jun] | - | Paços de Ferreira [A-jun] | 1:3 | ||||
| 18. Ronde | 18.12.2021 | FC Porto [A-jun] | - | Vitória Guimarães [A-jun] | 1:1 | |
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| 14. Ronde | 22.12.2021 | Vitória Guimarães [A-jun] | - | Gil Vicente [A-jun] | 1:0 | ||||
| 19. Ronde | 08.01.2022 | Vitória Guimarães [A-jun] | - | Sporting Braga [A-jun] | 2:0 | ||||
| 20. Ronde | 15.01.2022 | CD Feirense [A-jun] | - | Vitória Guimarães [A-jun] | 0:2 | |
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| 21. Ronde | 22.01.2022 | Vitória Guimarães [A-jun] | - | FC Famalicão [A-jun] | 2:2 |  |
Portugal