| 2. Ronde | 18.09.2021 | US Alessandria 1912 [A-jun] | - | Pordenone Calcio [A-jun] | 0:4 | ||||
| 3. Ronde | 25.09.2021 | US Cremonese [A-jun] | - | US Alessandria 1912 [A-jun] | 5:3 | ||||
| 5. Ronde | 16.10.2021 | L.R. Vicenza [A-jun] | - | US Alessandria 1912 [A-jun] | 5:1 |  |
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| 6. Ronde | 23.10.2021 | US Alessandria 1912 [A-jun] | - | Como 1907 [A-jun] | 1:1 | ||||
| 7. Ronde | 30.10.2021 | AS Cittadella [A-jun] | - | US Alessandria 1912 [A-jun] | 1:0 | ||||
| 9. Ronde | 20.11.2021 | AC Monza [A-jun] | - | US Alessandria 1912 [A-jun] | 1:1 | ||||
| 16. Ronde | 12.02.2022 | US Alessandria 1912 [A-jun] | - | US Cremonese [A-jun] | 1:4 | ||||
| 17. Ronde | 19.02.2022 | Brescia Calcio [A-jun] | - | US Alessandria 1912 [A-jun] | 3:2 | ||||
| 18. Ronde | 26.02.2022 | US Alessandria 1912 [A-jun] | - | L.R. Vicenza [A-jun] | 0:1 | ||||
| 21. Ronde | 19.03.2022 | Venezia FC [A-jun] | - | US Alessandria 1912 [A-jun] | 5:1 | ||||
| 22. Ronde | 26.03.2022 | US Alessandria 1912 [A-jun] | - | AC Monza [A-jun] | 2:3 | ||||
| 23. Ronde | 02.04.2022 | Virtus Entella [A-jun] | - | US Alessandria 1912 [A-jun] | 0:0 |
Italië