| 2. Ronde | 12.09.2021 | Delfino Pescara [A-jun] | - | Empoli FC [A-jun] | 0:0 | ||||
| 3. Ronde | 18.09.2021 | Empoli FC [A-jun] | - | SPAL 2013 Ferrara [A-jun] | 6:0 | ||||
| 5. Ronde | 16.10.2021 | Empoli FC [A-jun] | - | Inter [A-jun] | 1:1 | ||||
| 6. Ronde | 24.10.2021 | AS Roma [A-jun] | - | Empoli FC [A-jun] | 2:2 | ||||
| 11. Ronde | 05.12.2021 | Empoli FC [A-jun] | - | Atalanta [A-jun] | 1:1 | ||||
| 12. Ronde | 13.12.2021 | Bologna FC [A-jun] | - | Empoli FC [A-jun] | 3:0 | ||||
| 14. Ronde | 21.12.2021 | Empoli FC [A-jun] | - | Sassuolo Calcio [A-jun] | 0:2 | ||||
| 15. Ronde | 29.01.2022 | AC Milan [A-jun] | - | Empoli FC [A-jun] | 3:1 | ||||
| 16. Ronde | 01.02.2022 | Empoli FC [A-jun] | - | Genoa CFC [A-jun] | 0:1 | ||||
| 17. Ronde | 04.02.2022 | Cagliari Calcio [A-jun] | - | Empoli FC [A-jun] | 2:0 |
Italië