| 14. Ronde | 29.01.2022 | US Alessandria 1912 [A-jun] | - | Parma Calcio 1913 [A-jun] | 1:4 | ||||
| 15. Ronde | 05.02.2022 | Pordenone Calcio [A-jun] | - | US Alessandria 1912 [A-jun] | 0:2 |  |
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| 16. Ronde | 12.02.2022 | US Alessandria 1912 [A-jun] | - | US Cremonese [A-jun] | 1:4 | ||||
| 17. Ronde | 19.02.2022 | Brescia Calcio [A-jun] | - | US Alessandria 1912 [A-jun] | 3:2 | ||||
| 18. Ronde | 26.02.2022 | US Alessandria 1912 [A-jun] | - | L.R. Vicenza [A-jun] | 0:1 | |
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| 19. Ronde | 07.03.2022 | Como 1907 [A-jun] | - | US Alessandria 1912 [A-jun] | 4:4 |  |
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| 20. Ronde | 12.03.2022 | US Alessandria 1912 [A-jun] | - | AS Cittadella [A-jun] | 3:3 | ||||
| 22. Ronde | 26.03.2022 | US Alessandria 1912 [A-jun] | - | AC Monza [A-jun] | 2:3 | |
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| 23. Ronde | 02.04.2022 | Virtus Entella [A-jun] | - | US Alessandria 1912 [A-jun] | 0:0 | ||||
| 24. Ronde | 09.04.2022 | US Alessandria 1912 [A-jun] | - | AC Reggiana 1919 [A-jun] | 4:0 | |
Italië