| 7. Ronde | 22.01.2021 | Ascoli Calcio [A-jun] | - | Sampdoria [A-jun] | 1:3 |  |
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| 4. Ronde | 26.01.2021 | Sampdoria [A-jun] | - | Empoli FC [A-jun] | 4:1 | |
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| 12. Ronde | 28.02.2021 | Sampdoria [A-jun] | - | AS Roma [A-jun] | 1:1 | ||||
| 17. Ronde | 03.04.2021 | Lazio Roma [A-jun] | - | Sampdoria [A-jun] | 1:4 | ||||
| 21. Ronde | 01.05.2021 | SPAL 2013 Ferrara [A-jun] | - | Sampdoria [A-jun] | 2:1 | ||||
| 22. Ronde | 08.05.2021 | Sampdoria [A-jun] | - | Ascoli Calcio [A-jun] | 6:1 | ||||
| 25. Ronde | 26.05.2021 | Sampdoria [A-jun] | - | Sassuolo Calcio [A-jun] | 1:1 | ||||
| 26. Ronde | 29.05.2021 | AC Milan [A-jun] | - | Sampdoria [A-jun] | 0:2 | ||||
| 27. Ronde | 06.06.2021 | AS Roma [A-jun] | - | Sampdoria [A-jun] | 2:2 | ||||
| 28. Ronde | 09.06.2021 | Sampdoria [A-jun] | - | Cagliari Calcio [A-jun] | 1:0 | ||||
| 29. Ronde | 12.06.2021 | ACF Fiorentina [A-jun] | - | Sampdoria [A-jun] | 1:1 | ||||
| 30. Ronde | 16.06.2021 | Sampdoria [A-jun] | - | Torino FC [A-jun] | 5:0 | |
Italië