| 2. Ronde | 18.09.2021 | Spezia Calcio [A-jun] | - | Benevento Calcio [A-jun] | 2:1 | ||||
| 3. Ronde | 25.09.2021 | Frosinone Calcio [A-jun] | - | Spezia Calcio [A-jun] | 2:0 | ||||
| 4. Ronde | 02.10.2021 | Spezia Calcio [A-jun] | - | Cesena FC [A-jun] | 2:6 | ||||
| 5. Ronde | 16.10.2021 | Ternana Calcio [A-jun] | - | Spezia Calcio [A-jun] | 0:2 | ||||
| 7. Ronde | 31.10.2021 | Spezia Calcio [A-jun] | - | Pisa SC [A-jun] | 1:0 | ||||
| 20. Ronde | 12.03.2022 | Pisa SC [A-jun] | - | Spezia Calcio [A-jun] | 3:0 | ||||
| 14. Ronde | 15.03.2022 | Spezia Calcio [A-jun] | - | FC Crotone [A-jun] | 4:3 | ||||
| 22. Ronde | 26.03.2022 | AC Perugia Calcio [A-jun] | - | Spezia Calcio [A-jun] | 3:1 | ||||
| 23. Ronde | 02.04.2022 | Spezia Calcio [A-jun] | - | US Salernitana 1919 [A-jun] | 1:1 |
Italië