| 5. Ronde | 16.10.2021 | Cosenza Calcio [A-jun] | - | Frosinone Calcio [A-jun] | 1:5 | ||||
| 7. Ronde | 30.10.2021 | Benevento Calcio [A-jun] | - | Frosinone Calcio [A-jun] | 3:0 Toeg. | ||||
| 10. Ronde | 27.11.2021 | AC Perugia Calcio [A-jun] | - | Frosinone Calcio [A-jun] | 2:2 | ||||
| 11. Ronde | 04.12.2021 | Frosinone Calcio [A-jun] | - | US Salernitana 1919 [A-jun] | 3:2 | ||||
| 12. Ronde | 11.12.2021 | Cesena FC [A-jun] | - | Frosinone Calcio [A-jun] | 4:2 |  |
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| 13. Ronde | 18.12.2021 | Frosinone Calcio [A-jun] | - | Ascoli Calcio [A-jun] | 3:1 | ||||
| 14. Ronde | 29.01.2022 | Reggina 1914 [A-jun] | - | Frosinone Calcio [A-jun] | 2:3 | ||||
| 15. Ronde | 05.02.2022 | Frosinone Calcio [A-jun] | - | Pisa SC [A-jun] | 2:5 |  |
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| 22. Ronde | 27.03.2022 | Lazio Roma [A-jun] | - | Frosinone Calcio [A-jun] | 2:1 | ||||
| 24. Ronde | 09.04.2022 | US Salernitana 1919 [A-jun] | - | Frosinone Calcio [A-jun] | 1:3 | |
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| 25. Ronde | 16.04.2022 | Frosinone Calcio [A-jun] | - | Cesena FC [A-jun] | 2:1 |  |
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| 26. Ronde | 23.04.2022 | Ascoli Calcio [A-jun] | - | Frosinone Calcio [A-jun] | 0:2 |
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