| 5. Ronde | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Ronde | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 |  |
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| 7. Ronde | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Ronde | 24.08.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 10. Ronde | 03.09.2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | |
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| 12. Ronde | 17.09.2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Ronde | 24.09.2021 | Newell's Old Boys II | - | Huracán II | 2:0 | |
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| 14. Ronde | 01.10.2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 | ||||
| 15. Ronde | 08.10.2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 17. Ronde | 18.10.2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | |
Argentinië