| 1. Ronde | 16.07.2021 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 | ||||
| 2. Ronde | 23.07.2021 | San Lorenzo II | - | Central Córdoba SdE II | 1:0 | ||||
| 4. Ronde | 30.07.2021 | San Lorenzo II | - | Banfield II | 2:3 | ||||
| 5. Ronde | 06.08.2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 14. Ronde | 01.10.2021 | Atlético Tucumán II | - | San Lorenzo II | 1:1 |  |
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| 15. Ronde | 11.10.2021 | San Lorenzo II | - | Colón de Santa Fe II | 1:1 | ||||
| 16. Ronde | 15.10.2021 | River Plate II | - | San Lorenzo II | 1:3 | |
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| 17. Ronde | 18.10.2021 | San Lorenzo II | - | Lanús II | 0:0 | ||||
| 18. Ronde | 22.10.2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
| 19. Ronde | 31.10.2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 20. Ronde | 05.11.2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 3. Ronde | 11.11.2021 | Boca Juniors II | - | San Lorenzo II | 4:1 | ||||
| 21. Ronde | 18.11.2021 | San Lorenzo II | - | Gimnasia de La Plata II | 4:1 | ||||
| 22. Ronde | 23.11.2021 | Aldosivi II | - | San Lorenzo II | 1:0 | ||||
| 25. Ronde | 10.12.2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentinië