| 1. Ronde | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 |  |
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| 2. Ronde | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 | ||||
| 3. Ronde | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 7. Ronde | 15.02.2021 | Defensor Sporting | - | Fénix | 2:2 | ||||
| 8. Ronde | 18.02.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 9. Ronde | 20.02.2021 | Defensor Sporting | - | Liverpool | 0:3 | |
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| 11. Ronde | 08.03.2021 | Nacional | - | Defensor Sporting | 2:1 | |
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| 12. Ronde | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | |
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