| 3. Ronde | 27.07.2021 | Newell's Old Boys II | - | Estudiantes II | 1:3 | ||||
| 4. Ronde | 30.07.2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 5. Ronde | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Ronde | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Ronde | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Ronde | 24.08.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Ronde | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 10. Ronde | 03.09.2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Ronde | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Ronde | 17.09.2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 15. Ronde | 08.10.2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 18. Ronde | 22.10.2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 19. Ronde | 29.10.2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
| 22. Ronde | 24.11.2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 |
Argentinië