| 2. Ronde | 11.09.2021 | Inter [A-jun] | - | ACF Fiorentina [A-jun] | 3:3 | ||||
| 11. Ronde | 05.12.2021 | US Lecce [A-jun] | - | ACF Fiorentina [A-jun] | 0:0 | ||||
| 12. Ronde | 13.12.2021 | ACF Fiorentina [A-jun] | - | Torino FC [A-jun] | 2:3 |  |
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| 15. Ronde | 28.01.2022 | ACF Fiorentina [A-jun] | - | Bologna FC [A-jun] | 2:1 | ||||
| 16. Ronde | 01.02.2022 | Sampdoria [A-jun] | - | ACF Fiorentina [A-jun] | 4:1 | ||||
| 17. Ronde | 05.02.2022 | ACF Fiorentina [A-jun] | - | AS Roma [A-jun] | 2:1 | |
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| 13. Ronde | 09.02.2022 | SPAL 2013 Ferrara [A-jun] | - | ACF Fiorentina [A-jun] | 0:2 | ||||
| 19. Ronde | 16.02.2022 | ACF Fiorentina [A-jun] | - | Inter [A-jun] | 3:1 |  |
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| 21. Ronde | 26.02.2022 | Sassuolo Calcio [A-jun] | - | ACF Fiorentina [A-jun] | 3:0 | ||||
| 22. Ronde | 05.03.2022 | ACF Fiorentina [A-jun] | - | Hellas Verona [A-jun] | 2:0 | ||||
| 24. Ronde | 13.03.2022 | ACF Fiorentina [A-jun] | - | AC Milan [A-jun] | 3:1 | ||||
| 27. Ronde | 10.04.2022 | Genoa CFC [A-jun] | - | ACF Fiorentina [A-jun] | 1:1 | ||||
| 32. Ronde | 30.04.2022 | Bologna FC [A-jun] | - | ACF Fiorentina [A-jun] | 1:0 | ||||
| 33. Ronde | 09.05.2022 | ACF Fiorentina [A-jun] | - | Sampdoria [A-jun] | 1:2 |
Italië