| 1. Ronde | 28.08.2021 | Fermana FC | - | Viterbese | 3:3 | ||||
| 2. Ronde | 05.09.2021 | AS Gubbio | - | Fermana FC | 1:0 | ||||
| 3. Ronde | 12.09.2021 | Fermana FC | - | Aquila Montevarchi | 0:1 |  |
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| 6. Ronde | 28.09.2021 | Fermana FC | - | US Grosseto FC | 2:0 | ||||
| 7. Ronde | 02.10.2021 | Vis Pesaro | - | Fermana FC | 2:0 | ||||
| 8. Ronde | 09.10.2021 | Fermana FC | - | ACN Siena 1904 | 1:1 | ||||
| 9. Ronde | 16.10.2021 | Delfino Pescara | - | Fermana FC | 2:1 | ||||
| 10. Ronde | 19.10.2021 | Fermana FC | - | Lucchese | 0:0 | ||||
| 11. Ronde | 23.10.2021 | Ancona 1905 | - | Fermana FC | 1:2 | ||||
| 13. Ronde | 07.11.2021 | SSD Città di Teramo | - | Fermana FC | 3:2 | ||||
| 21. Ronde | 02.02.2022 | Fermana FC | - | AS Gubbio | 1:1 | ||||
| 25. Ronde | 06.02.2022 | US Grosseto FC | - | Fermana FC | 0:0 | ||||
| 22. Ronde | 23.02.2022 | Aquila Montevarchi | - | Fermana FC | 2:0 | ||||
| 33. Ronde | 19.03.2022 | US Pistoiese | - | Fermana FC | 2:1 | ||||
| 34. Ronde | 27.03.2022 | Fermana FC | - | Cesena FC | 2:2 | ||||
| 38. Ronde | 23.04.2022 | Virtus Entella | - | Fermana FC | 2:1 |
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