| 1. Ronde | 09.01.2021 | Club Tijuana | - | Pumas UNAM | 0:0 | ||||
| 2. Ronde | 17.01.2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 3. Ronde | 25.01.2021 | Gallos Blancos | - | Pumas UNAM | 2:0 | ||||
| 4. Ronde | 31.01.2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 5. Ronde | 07.02.2021 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 6. Ronde | 14.02.2021 | Deportivo Toluca | - | Pumas UNAM | 1:0 |  |
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| 7. Ronde | 21.02.2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 8. Ronde | 01.03.2021 | Deportivo Guadalajara | - | Pumas UNAM | 2:1 | |
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| 9. Ronde | 05.03.2021 | Pumas UNAM | - | Santos Laguna | 1:0 | |
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| 10. Ronde | 08.03.2021 | Pumas UNAM | - | Cruz Azul | 0:1 | |
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| 11. Ronde | 13.03.2021 | FC Juárez | - | Pumas UNAM | 1:1 | |
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| 13. Ronde | 04.04.2021 | Pumas UNAM | - | CF Pachuca | 2:2 | ||||
| 14. Ronde | 10.04.2021 | Club Necaxa | - | Pumas UNAM | 0:1 | ||||
| 15. Ronde | 18.04.2021 | Pumas UNAM | - | UANL Tigres | 0:0 | ||||
| 16. Ronde | 24.04.2021 | Puebla FC | - | Pumas UNAM | 0:0 | ||||
| 17. Ronde | 03.05.2021 | Pumas UNAM | - | CF América | 0:1 | |
Mexico