| 1. Ronde | 19.08.2024 | US Lecce | - | Atalanta | 0:4 | ||||
| 2. Ronde | 24.08.2024 | Inter | - | US Lecce | 2:0 |  |
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| 3. Ronde | 31.08.2024 | US Lecce | - | Cagliari Calcio | 1:0 | ||||
| 5. Ronde | 21.09.2024 | US Lecce | - | Parma Calcio 1913 | 2:2 | ||||
| 6. Ronde | 27.09.2024 | AC Milan | - | US Lecce | 3:0 | ||||
| 8. Ronde | 20.10.2024 | US Lecce | - | ACF Fiorentina | 0:6 | ||||
| 9. Ronde | 26.10.2024 | SSC Napoli | - | US Lecce | 1:0 | ||||
| 10. Ronde | 29.10.2024 | US Lecce | - | Hellas Verona | 1:0 | ||||
| 11. Ronde | 02.11.2024 | Bologna FC | - | US Lecce | 1:0 | ||||
| 12. Ronde | 08.11.2024 | US Lecce | - | Empoli FC | 1:1 | ||||
| 28. Ronde | 08.03.2025 | US Lecce | - | AC Milan | 2:3 | ||||
| 29. Ronde | 14.03.2025 | Genoa CFC | - | US Lecce | 2:1 | ||||
| 30. Ronde | 29.03.2025 | US Lecce | - | AS Roma | 0:1 | ||||
| 33. Ronde | 19.04.2025 | US Lecce | - | Como 1907 | 0:3 | ||||
| 36. Ronde | 11.05.2025 | Hellas Verona | - | US Lecce | 1:1 |
Zambia