| 7. Ronde | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Ronde | 24.08.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 9. Ronde | 30.08.2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 10. Ronde | 03.09.2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 11. Ronde | 14.09.2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Ronde | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 16. Ronde | 13.10.2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Ronde | 18.10.2021 | Platense II | - | Rosario Central II | 0:3 |  |
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| 18. Ronde | 24.10.2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 19. Ronde | 29.10.2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 21. Ronde | 20.11.2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | |
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| 22. Ronde | 24.11.2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Ronde | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Ronde | 03.12.2021 | Lanús II | - | Rosario Central II | 2:3 | |
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| 25. Ronde | 10.12.2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentinië