| 1. Ronde | 13.09.2021 | FC Crotone [A-jun] | - | Spezia Calcio [A-jun] | 4:2 | ||||
| 2. Ronde | 18.09.2021 | Spezia Calcio [A-jun] | - | Benevento Calcio [A-jun] | 2:1 | ||||
| 4. Ronde | 02.10.2021 | Spezia Calcio [A-jun] | - | Cesena FC [A-jun] | 2:6 | ||||
| 6. Ronde | 23.10.2021 | Spezia Calcio [A-jun] | - | Reggina 1914 [A-jun] | 7:2 |  |
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| 8. Ronde | 06.11.2021 | Lazio Roma [A-jun] | - | Spezia Calcio [A-jun] | 0:0 | ||||
| 10. Ronde | 27.11.2021 | US Salernitana 1919 [A-jun] | - | Spezia Calcio [A-jun] | 0:4 | ||||
| 15. Ronde | 05.02.2022 | Benevento Calcio [A-jun] | - | Spezia Calcio [A-jun] | 1:0 | ||||
| 16. Ronde | 12.02.2022 | Spezia Calcio [A-jun] | - | Frosinone Calcio [A-jun] | 2:2 | ||||
| 17. Ronde | 19.02.2022 | Cesena FC [A-jun] | - | Spezia Calcio [A-jun] | 2:0 |
Italië