| 1. Ronde | 26.09.2020 | US Lecce | - | Pordenone Calcio | 0:0 |  |
|||
| 2. Ronde | 03.10.2020 | Ascoli Calcio | - | US Lecce | 0:2 | ||||
| 3. Ronde | 16.10.2020 | Brescia Calcio | - | US Lecce | 3:0 | |
|||
| 4. Ronde | 21.10.2020 | US Lecce | - | US Cremonese | 2:2 | ||||
| 5. Ronde | 25.10.2020 | Cosenza Calcio | - | US Lecce | 1:1 | ||||
| 6. Ronde | 02.11.2020 | US Lecce | - | Delfino Pescara | 3:1 | ||||
| 7. Ronde | 08.11.2020 | Virtus Entella | - | US Lecce | 1:5 | |
|||
| 8. Ronde | 21.11.2020 | US Lecce | - | AC Reggiana 1919 | 7:1 |  |
|||
| 9. Ronde | 27.11.2020 | Chievo Verona | - | US Lecce | 1:2 | |
|||
| 11. Ronde | 12.12.2020 | US Lecce | - | Frosinone Calcio | 2:2 | ||||
| 12. Ronde | 15.12.2020 | US Salernitana 1919 | - | US Lecce | 1:1 | ||||
| 13. Ronde | 19.12.2020 | US Lecce | - | AC Pisa | 0:3 | ||||
| 14. Ronde | 22.12.2020 | SPAL 2013 Ferrara | - | US Lecce | 1:0 | ||||
| 16. Ronde | 30.12.2020 | AS Cittadella | - | US Lecce | 2:2 | ||||
| 18. Ronde | 16.01.2021 | Reggina 1914 | - | US Lecce | 0:1 |
Italië