| 1. Ronde | 11.09.2021 | AC Perugia Calcio [A-jun] | - | Lazio Roma [A-jun] | 1:2 | ||||
| 3. Ronde | 26.09.2021 | FC Crotone [A-jun] | - | AC Perugia Calcio [A-jun] | 1:3 |  |
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| 4. Ronde | 02.10.2021 | AC Perugia Calcio [A-jun] | - | Benevento Calcio [A-jun] | 6:2 | ||||
| 7. Ronde | 30.10.2021 | Cesena FC [A-jun] | - | AC Perugia Calcio [A-jun] | 3:2 | |
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| 8. Ronde | 06.11.2021 | AC Perugia Calcio [A-jun] | - | Cosenza Calcio [A-jun] | 1:4 | ||||
| 9. Ronde | 20.11.2021 | Spezia Calcio [A-jun] | - | AC Perugia Calcio [A-jun] | 0:1 | |
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| 13. Ronde | 18.12.2021 | Ternana Calcio [A-jun] | - | AC Perugia Calcio [A-jun] | 2:1 | ||||
| 11. Ronde | 22.12.2021 | Pisa SC [A-jun] | - | AC Perugia Calcio [A-jun] | 3:1 | ||||
| 14. Ronde | 29.01.2022 | Lazio Roma [A-jun] | - | AC Perugia Calcio [A-jun] | 4:0 | ||||
| 24. Ronde | 09.04.2022 | AC Perugia Calcio [A-jun] | - | Pisa SC [A-jun] | 1:2 |
Italië