| 4. Ronde | 11.09.2021 | Athletic Club | - | RCD Mallorca | 2:0 | ||||
| 7. Ronde | 25.09.2021 | Valencia CF | - | Athletic Club | 1:1 | ||||
| 13. Ronde | 05.11.2021 | Athletic Club | - | Cádiz CF | 0:1 | ||||
| 14. Ronde | 19.11.2021 | Levante UD | - | Athletic Club | 0:0 | ||||
| 21. Ronde | 22.12.2021 | Athletic Club | - | Real Madrid | 1:2 | ||||
| 19. Ronde | 03.01.2022 | CA Osasuna | - | Athletic Club | 1:3 | ||||
| 20. Ronde | 09.01.2022 | Deportivo Alavés | - | Athletic Club | 0:0 | ||||
| 22. Ronde | 23.01.2022 | Rayo Vallecano | - | Athletic Club | 0:1 |  |
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| 23. Ronde | 07.02.2022 | Athletic Club | - | Espanyol | 2:1 | ||||
| 26. Ronde | 27.02.2022 | FC Barcelona | - | Athletic Club | 4:0 | ||||
| 28. Ronde | 13.03.2022 | Real Betis | - | Athletic Club | 1:0 | ||||
| 29. Ronde | 18.03.2022 | Athletic Club | - | Getafe CF | 1:1 | ||||
| 32. Ronde | 17.04.2022 | Athletic Club | - | Celta de Vigo | 0:2 | ||||
| 38. Ronde | 22.05.2022 | Sevilla FC | - | Athletic Club | 1:0 |
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