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| 08.01.2022 | 14:00 | Levante UD | - | RCD Mallorca | 2:0 (0:0) | |
| 16:15 | Real Sociedad | - | Celta de Vigo | 1:0 (1:0) | ||
| 18:30 | Granada CF | - | FC Barcelona | 1:1 (0:0) | ||
| 21:00 | Real Madrid | - | Valencia CF | 4:1 (1:0) | ||
| 09.01.2022 | 14:00 | Rayo Vallecano | - | Real Betis | 1:1 (0:1) | |
| 16:15 | Sevilla FC | - | Getafe CF | 1:0 (1:0) | ||
| 18:30 | CA Osasuna | - | Cádiz CF | 2:0 (1:0) | ||
| 18:30 | Deportivo Alavés | - | Athletic Bilbao | 0:0 (0:0) | ||
| 21:00 | Villarreal CF | - | Atlético Madrid | 2:2 (1:1) | ||
| 10.01.2022 | 21:00 | Espanyol | - | Elche CF | 1:2 (1:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Madrid | 20 | 14 | 4 | 2 | 43:17 | 26 | 46 |
| 2 |
|
Sevilla FC | 20 | 13 | 5 | 2 | 31:13 | 18 | 44 |
| 3 |
|
Real Betis | 20 | 10 | 4 | 6 | 33:24 | 9 | 34 |
| 4 |
|
Atlético Madrid | 20 | 9 | 6 | 5 | 33:24 | 9 | 33 |
| 5 |
|
Real Sociedad | 20 | 9 | 6 | 5 | 22:21 | 1 | 33 |
| 6 |
|
FC Barcelona | 20 | 8 | 8 | 4 | 31:23 | 8 | 32 |
| 7 |
|
Rayo Vallecano | 20 | 9 | 4 | 7 | 27:21 | 6 | 31 |
| 8 |
|
Villarreal CF | 20 | 7 | 8 | 5 | 33:22 | 11 | 29 |
| 9 |
|
Valencia CF | 20 | 7 | 7 | 6 | 32:32 | 0 | 28 |
| 10 |
|
Athletic Bilbao | 20 | 6 | 10 | 4 | 19:15 | 4 | 28 |
| 11 |
|
Espanyol | 20 | 7 | 5 | 8 | 23:24 | -1 | 26 |
| 12 |
|
CA Osasuna | 20 | 6 | 7 | 7 | 20:25 | -5 | 25 |
| 13 |
|
Granada CF | 20 | 5 | 9 | 6 | 24:27 | -3 | 24 |
| 14 |
|
Celta de Vigo | 20 | 6 | 5 | 9 | 22:23 | -1 | 23 |
| 15 |
|
RCD Mallorca | 20 | 4 | 8 | 8 | 17:30 | -13 | 20 |
| 16 |
|
Elche CF | 20 | 4 | 7 | 9 | 20:28 | -8 | 19 |
| 17 |
|
Getafe CF | 20 | 4 | 6 | 10 | 13:21 | -8 | 18 |
| 18 |
|
Deportivo Alavés | 20 | 4 | 5 | 11 | 16:30 | -14 | 17 |
| 19 |
|
Cádiz CF | 20 | 2 | 8 | 10 | 15:34 | -19 | 14 |
| 20 |
|
Levante UD | 20 | 1 | 8 | 11 | 21:41 | -20 | 11 |
| Champions League | |
| Europa League | |
| Degradatie |
