| 3. Ronde | 02.09.2018 | Sampdoria | - | SSC Napoli | 3:0 |  |
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| 4. Ronde | 15.09.2018 | Frosinone Calcio | - | Sampdoria | 0:5 | ||||
| 12. Ronde | 11.11.2018 | AS Roma | - | Sampdoria | 4:1 | ||||
| 14. Ronde | 01.12.2018 | Sampdoria | - | Bologna FC | 4:1 | ||||
| 22. Ronde | 02.02.2019 | SSC Napoli | - | Sampdoria | 3:0 | ||||
| 24. Ronde | 17.02.2019 | Inter | - | Sampdoria | 2:1 | ||||
| 25. Ronde | 24.02.2019 | Sampdoria | - | Cagliari Calcio | 1:0 | ||||
| 26. Ronde | 03.03.2019 | SPAL 2013 Ferrara | - | Sampdoria | 1:2 | |
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| 28. Ronde | 16.03.2019 | Sassuolo Calcio | - | Sampdoria | 3:5 | ||||
| 29. Ronde | 30.03.2019 | Sampdoria | - | AC Milan | 1:0 | |
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| 30. Ronde | 03.04.2019 | Torino FC | - | Sampdoria | 2:1 | ||||
| 31. Ronde | 06.04.2019 | Sampdoria | - | AS Roma | 0:1 | ||||
| 36. Ronde | 12.05.2019 | Sampdoria | - | Empoli FC | 1:2 | ||||
| 38. Ronde | 26.05.2019 | Sampdoria | - | Juventus | 2:0 |
Guinea-Bissau