| 2. Ronde | 13.08.2021 | FC Lorient | - | AS Monaco | 1:0 | ||||
| 3. Ronde | 21.08.2021 | AS Monaco | - | RC Lens | 0:2 |  |
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| 6. Ronde | 19.09.2021 | OGC Nice | - | AS Monaco | 2:2 | ||||
| 7. Ronde | 22.09.2021 | AS Monaco | - | AS Saint-Étienne | 3:1 | ||||
| 8. Ronde | 26.09.2021 | Clermont Foot 63 | - | AS Monaco | 1:3 | |
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| 11. Ronde | 24.10.2021 | AS Monaco | - | Montpellier HSC | 3:1 | ||||
| 14. Ronde | 19.11.2021 | AS Monaco | - | Lille OSC | 2:2 |  |
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