| 1. Ronde | 13.08.2022 | US Lecce | - | Inter | 1:2 | ||||
| 2. Ronde | 20.08.2022 | Sassuolo Calcio | - | US Lecce | 1:0 | ||||
| 4. Ronde | 31.08.2022 | SSC Napoli | - | US Lecce | 1:1 | ||||
| 6. Ronde | 11.09.2022 | US Lecce | - | AC Monza | 1:1 | ||||
| 9. Ronde | 09.10.2022 | AS Roma | - | US Lecce | 2:1 | ||||
| 10. Ronde | 17.10.2022 | US Lecce | - | ACF Fiorentina | 1:1 | ||||
| 21. Ronde | 04.02.2023 | US Cremonese | - | US Lecce | 0:2 | ||||
| 25. Ronde | 05.03.2023 | Inter | - | US Lecce | 2:0 | ||||
| 27. Ronde | 19.03.2023 | ACF Fiorentina | - | US Lecce | 1:0 | ||||
| 28. Ronde | 03.04.2023 | Empoli FC | - | US Lecce | 1:0 | ||||
| 29. Ronde | 07.04.2023 | US Lecce | - | SSC Napoli | 1:2 | ||||
| 35. Ronde | 12.05.2023 | Lazio | - | US Lecce | 2:2 |
IJsland