| 3. Ronde | 21.08.2021 | Vitória Setúbal [A-jun] | - | Sporting CP [A-jun] | 0:1 | ||||
| 2. Ronde | 04.09.2021 | Vitória Setúbal [A-jun] | - | União Leiria [A-jun] | 4:3 | ||||
| 9. Ronde | 16.10.2021 | Vitória Setúbal [A-jun] | - | UD Vilafranquense [A-jun] | 4:1 | ||||
| 10. Ronde | 23.10.2021 | Académica de Coimbra [A-jun] | - | Vitória Setúbal [A-jun] | 1:2 | ||||
| 11. Ronde | 30.10.2021 | Vitória Setúbal [A-jun] | - | SG Sacavenense [A-jun] | 3:2 | ||||
| 14. Ronde | 27.11.2021 | Sporting CP [A-jun] | - | Vitória Setúbal [A-jun] | 4:0 | ||||
| 15. Ronde | 01.12.2021 | Vitória Setúbal [A-jun] | - | FC Alverca [A-jun] | 0:4 |  |
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| 20. Ronde | 15.01.2022 | UD Vilafranquense [A-jun] | - | Vitória Setúbal [A-jun] | 0:1 |  |
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| 21. Ronde | 22.01.2022 | Vitória Setúbal [A-jun] | - | Académica de Coimbra [A-jun] | 1:1 |
Portugal