| 2. Ronde | 18.09.2021 | Pisa SC [A-jun] | - | Frosinone Calcio [A-jun] | 3:1 | ||||
| 3. Ronde | 25.09.2021 | Cosenza Calcio [A-jun] | - | Pisa SC [A-jun] | 2:1 | ||||
| 7. Ronde | 31.10.2021 | Spezia Calcio [A-jun] | - | Pisa SC [A-jun] | 1:0 | ||||
| 12. Ronde | 11.12.2021 | Lazio Roma [A-jun] | - | Pisa SC [A-jun] | 3:0 | ||||
| 13. Ronde | 18.12.2021 | Pisa SC [A-jun] | - | Benevento Calcio [A-jun] | 1:0 | ||||
| 11. Ronde | 22.12.2021 | Pisa SC [A-jun] | - | AC Perugia Calcio [A-jun] | 3:1 | ||||
| 14. Ronde | 29.01.2022 | Pisa SC [A-jun] | - | Ternana Calcio [A-jun] | 1:0 | ||||
| 15. Ronde | 05.02.2022 | Frosinone Calcio [A-jun] | - | Pisa SC [A-jun] | 2:5 | ||||
| 19. Ronde | 05.03.2022 | US Salernitana 1919 [A-jun] | - | Pisa SC [A-jun] | 2:1 | ||||
| 23. Ronde | 02.04.2022 | FC Crotone [A-jun] | - | Pisa SC [A-jun] | 1:0 | ||||
| 26. Ronde | 23.04.2022 | Benevento Calcio [A-jun] | - | Pisa SC [A-jun] | 1:2 |  |
Italië