| 5. Ronde | 16.10.2021 | Cesena FC [A-jun] | - | Pisa SC [A-jun] | 3:2 |  |
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| 7. Ronde | 31.10.2021 | Spezia Calcio [A-jun] | - | Pisa SC [A-jun] | 1:0 | ||||
| 8. Ronde | 06.11.2021 | Pisa SC [A-jun] | - | Reggina 1914 [A-jun] | 0:0 | ||||
| 11. Ronde | 22.12.2021 | Pisa SC [A-jun] | - | AC Perugia Calcio [A-jun] | 3:1 | ||||
| 19. Ronde | 05.03.2022 | US Salernitana 1919 [A-jun] | - | Pisa SC [A-jun] | 2:1 | ||||
| 21. Ronde | 19.03.2022 | Reggina 1914 [A-jun] | - | Pisa SC [A-jun] | 0:2 |
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