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| 03.03.2022 | 13:00 | Gimnasia de La Plata II | - | Argentinos Juniors II | 1:0 (1:0) | |
| 13:00 | Patronato de Paraná II | - | Sarmiento de Junín II | 1:2 (1:0) | ||
| 13:00 | Arsenal de Sarandí II | - | Lanús II | 1:1 (0:0) | ||
| 13:00 | Boca Juniors II | - | Huracán II | 1:1 (1:1) | ||
| 13:00 | Tigre II | - | Colón de Santa Fe II | 1:0 (0:0) | ||
| 04.03.2022 | 13:00 | Banfield II | - | Defensa y Justicia II | 2:0 (1:0) | |
| 13:00 | San Lorenzo II | - | River Plate II | 0:4 (0:2) | ||
| 13:00 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 (1:1) | ||
| 13:00 | Godoy Cruz II | - | Independiente II | 0:2 (0:1) | ||
| 13:00 | Central Córdoba SdE II | - | Rosario Central II | 0:3 (0:1) | ||
| 13:00 | Barracas Central II | - | Aldosivi II | 0:2 (0:0) | ||
| 05.03.2022 | 13:00 | Vélez Sarsfield II | - | Estudiantes II | 0:2 (0:2) | |
| 06.03.2022 | 13:00 | Racing Club II | - | Talleres de Córdoba II | 1:2 (0:2) | |
| 28.03.2022 | 14:00 | Unión de Santa Fe II | - | Platense II | 0:4 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Banfield II | 5 | 5 | 0 | 0 | 11:5 | 6 | 15 |
| 2 |
|
River Plate II | 5 | 4 | 1 | 0 | 11:3 | 8 | 13 |
| 3 |
|
Argentinos Juniors II | 5 | 3 | 1 | 1 | 8:2 | 6 | 10 |
| 4 |
|
Sarmiento de Junín II | 5 | 3 | 1 | 1 | 7:4 | 3 | 10 |
| 5 |
|
Talleres de Córdoba II | 5 | 2 | 3 | 0 | 11:5 | 6 | 9 |
| 6 |
|
Atlético Tucumán II | 5 | 3 | 0 | 2 | 11:7 | 4 | 9 |
| 7 |
|
Gimnasia de La Plata II | 5 | 3 | 0 | 2 | 10:8 | 2 | 9 |
| 8 |
|
Defensa y Justicia II | 5 | 3 | 0 | 2 | 7:5 | 2 | 9 |
| 9 |
|
Platense II | 5 | 1 | 2 | 2 | 8:7 | 1 | 5 |
| 10 |
|
Newell's Old Boys II | 5 | 1 | 2 | 2 | 8:8 | 0 | 5 |
| 11 |
|
Unión de Santa Fe II | 5 | 1 | 1 | 3 | 1:11 | -10 | 4 |
| 12 |
|
Patronato de Paraná II | 5 | 0 | 1 | 4 | 3:9 | -6 | 1 |
| 13 |
|
Racing Club II | 5 | 0 | 0 | 5 | 4:14 | -10 | 0 |
| 14 |
|
San Lorenzo II | 5 | 0 | 0 | 5 | 2:14 | -12 | 0 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tigre II | 5 | 3 | 2 | 0 | 9:2 | 7 | 11 |
| 2 |
|
Central Córdoba SdE II | 5 | 3 | 1 | 1 | 9:5 | 4 | 10 |
| 3 |
|
Estudiantes II | 5 | 3 | 1 | 1 | 10:8 | 2 | 10 |
| 4 |
|
Aldosivi II | 5 | 3 | 0 | 2 | 10:6 | 4 | 9 |
| 5 |
|
Rosario Central II | 5 | 2 | 2 | 1 | 10:4 | 6 | 8 |
| 6 |
|
Arsenal de Sarandí II | 5 | 2 | 2 | 1 | 6:5 | 1 | 8 |
| 7 |
|
Vélez Sarsfield II | 5 | 2 | 2 | 1 | 7:7 | 0 | 8 |
| 8 |
|
Independiente II | 5 | 1 | 4 | 0 | 7:5 | 2 | 7 |
| 9 |
|
Colón de Santa Fe II | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 10 |
|
Lanús II | 5 | 1 | 2 | 2 | 7:8 | -1 | 5 |
| 11 |
|
Boca Juniors II | 5 | 0 | 4 | 1 | 4:5 | -1 | 4 |
| 12 |
|
Huracán II | 5 | 1 | 1 | 3 | 6:8 | -2 | 4 |
| 13 |
|
Barracas Central II | 5 | 1 | 0 | 4 | 5:14 | -9 | 3 |
| 14 |
|
Godoy Cruz II | 5 | 0 | 0 | 5 | 2:14 | -12 | 0 |
| Play-offs | |
| Play-offs |
